The SIRT5 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to sirt5, and sirtuin 5. This antibody recognizes Human, and Mouse antigen. The SIRT5 Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT5 localizes to mitochondria, deacetylates carbamoyl phosphate synthetase 1, and is involved in the regulation of the urea cycle